The dynamic marker technique has a broad range of important biomedical potentials e.g.:
1. Targeted drug delivery
2. Virus like rolling of magnetic beads above cell surfaces
3. Invading cells…
4. Immobilization inside cell organelles
5. Apoptotic chain reactions.
6. Improvement of insulin secretion
3 The Principle
Interaction of Fieldgenerator and SPIONparticles
A field generator interacts – magnetically – with the unpaired spins of super paramagnetic iron oxide nanoparticles (SPIONs). The SPIONs possess own field directions, which are the so called easy axis (in a cube shape – like here – the crystal owns 8 easy axis..111,111,1-11,1-1-1,-111,-11-1,-1-11,-1-1-1).
The unpaired SPION spins normally align along their easy axis’s – in fact they oscillate between these eight directions – and they can be viewed as the SPION’s own magnetic field.
A strong incoming field (field generator) synchronizes the SPION spin’s and restructures hereby their energy landscape, meaning, the still existing easy axis inside the crystal are gaining an angle towards their magnetization vector M, which approaches the incoming field vector H. This effect causes a Spion to move in order to minimize its energy.
Short
Strong invading field synchronizes (First spin movement – the precession) – and then moves the spins (Second spin movement – the synchronized field/spin motion), hereby new energy minima are created (Energy dissipation).
The SPION has to move macroscopically (Third (observable) movement) to align its easy axis’s/spins (Energy Saving).
Key Words
First spin movement – the precession
Second spin movement – the synchronized field/spin motion
Energy dissipation
Third macroscopic movement
Energy Saving
- Targeted drug delivery
- Virus like rolling of magnetic beads above cell surfaces
- Invading cells…
- Immobilization inside cell organelles
- Apoptotic chain reactions.
- Improvement of insulin secretion
3 The DFS Principle
Interaction of a field generator and magnetic particles (e.g. Spions).
A field generator interacts – magnetically – with the unpaired spins of super paramagnetic iron oxide nanoparticles (Spions). The Spions possess own field directions, which are the so called easy axis (in a cube shape – like here – the crystal owns 8 easy axis..111,111,1-11,1-1-1,-111,-11-1,-1-11,-1-1-1).
The unpaired Spion spins normally align along their easy axis’s – in fact they oscillate between these eight directions – and they can be viewed as the Spion’s own magnetic field.
A strong incoming field (e.g. from a field generator) synchronizes the Spion spin’s and restructures hereby their energy landscape, meaning, the still existing easy axis inside the crystal are gaining an angle towards their magnetization vector M, which approaches the incoming field vector H. This effect causes a Spion to move in order to minimize its energy.
Short
Strong invading field synchronizes (First spin movement – the precession) – and then moves the spins (Second spin movement – the synchronized field/spin motion), hereby new energy minima are created (Energy dissipation).
The Spion has to move macroscopically (Third (observable) movement) to align its easy axis’s/spins (Energy (angular moment) Saving).
Key Words
First spin movement – the precession
Second spin movement – the synchronized field/spin motion
Energy dissipation
Third macroscopic movement
Energy Saving